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Adeno-Associated Virus (AAV)
Adeno-associated virus (AAV) was discovered in 1965, as a contaminant of adenovirus (Ad) preparations, hence the name. It is replication-defective, non-enveloped small viruses (20nm) with a genome of
Biosafety
Recombinant viruses are replication deficient and can infect a broad range of mammalian cell types. Please refer to your institutions Occuptation Health and Safety office for guidance on safe handling
Efficient transduction of vascular endothelial cell with serotype BR1 and Vec
Vascular endothelium, as a functional tissue of human body, has the functions of barrier, synthesis, secretion and antithrombotic, etc. Studies have found that its dysfunction is closely related
Efficient transduction of Retinal tissue with rAAVs vectors
AAV-mediated gene therapy in Dystrophin-Dp71 deficient mouse leads to blood-retinal barrier restoration and oedema reabsorption