Fig1. Schematic representation of PRV Bartha strain retrograde transsynaptic transmission (Ekstrand MI et al.Trends Mol Med.2008).
After years of research, BrainVTA has established a stable production platform, and could offer pseudorabies virus(PRV) services to promote PRV-based neuronal tracing studies.
Applications
● Multisynaptic tracing from the peripheral to brain center, or the higher to the lower brain region.
● Tracking peripheral organs' connections to the central nervous system.
● Tracking the neural networks in disease or injury model.
● Changes in neural networks during neural development.
Fig2. Mice were infected PRV for 48h
Popular PRV particles
| Cat# | Name | Description | Price |
|---|---|---|---|
| P03001 | PRV-CAG-EGFP | Retrograde, multisynaptic | Inquiry |
| P03002 | PRV-CAG-mRFP | Retrograde, multisynaptic | Inquiry |
| P04001 | PRV-△TK-Ubc-DsRed | Delete TK, Retrograde | Inquiry |
| P04002 | PRV-CMV-ΔTK-LSL-EGFP-2A-TK | Retrograde, multisynaptic, Cre dependent | Inquiry |
Successful case
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Wangxiaojun. Plastic embedding immunolabeled large volume samples for three-dimensional high-resolution imaging. doi: 10.1364/BOE.8.003583.
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Zhijian Zhang, Hongruo Zhang, Pengjie Wen, Xutao Zhu, Li Wang, Qing Liu, Jie Wang, Xiaobin He, Huadong Wang and Fuqiang Xu. Whole-Brain Mapping of the Inputs and Outputs of the Medial Part of the Olfactory Tubercle. https://doi.org/10.3389/fncir.2017.00052.
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Hao-Long Zeng, Fei-Long Yu, Zhijian Zhang, Qing Yang, Sen Jin, Xiaobin He. Quantitative proteomics study of host response to virulent and attenuated pseudorabies virus infection in mouse brain. https://doi.org/10.1016/j.bbapap.2017.11.010.
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Haixia Liu, Xutao Zhu, Yun Ling, Xiaobin He, Lei Pei, Zhidan Zhang, Fang Yang, Fuqiang Xu. Corticosterone signaling and a lateral habenula-ventral tegmental area circuit modulate compulsive self-injurious behavior in a rat model. https://doi.org/10.1167/iovs.18-24308.